I just started getting into podcasting lately, not the casting part but listening to them, and my favourite is ThisWEEKinTECH. It’s all the former TechTV people before it went down the tubes. They get together every Sunday and talk about various areas of technology. Basically just a bunch of geek speak but it’s also entertaining for the “lite geek” too, as they tend to have this goofy chemistry together and joke around quite a bit.
Also, one of the TechTV people, Kevin Rose, started an online tech show called Systm. You can go grab their pilot episode in a few formats. Kevin and his crew also do thebroken which are darker hackerly type vids he started a while back.